Experience with degarelix in the treatment of prostate cancer

Degarelix is a gonadotrophin-releasing hormone (GnRH) antagonist for the first-line treatment of androgen-dependent advanced prostate cancer.It has a direct mechanism of action that blocks the action of GnRH on the pituitary with no initial surge in gonadotrophin or testosterone levels.Degarelix is the most extensively studied and widely available

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OTUD5 regulates p53 stability by deubiquitinating p53.

The p53 tumour suppressor protein is a transcription factor that prevents oncogenic progression by activating the expression of apoptosis and cell-cycle arrest genes in stressed cells.The stability of p53 is tightly regulated by ubiquitin-dependent degradation, driven mainly by its negative regulators ubiquitin ligase MDM2.In this study, we have id

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Influence of soundtrack on eye movements during video exploration

Models of visual attention remtavares.com rely on visual features such as orientation, intensity or motion to predict which regions of complex scenes attract the gaze of observers.So far, sound has never been considered as a possible feature that might influence eye movements.Here, we evaluate the impact of non-spatial sound on the eye movements of

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Exploring extended Higgs sectors via pair production at the LHC

Abstract Higgs sectors extended here by electroweakly charged scalars can be explored by scalar pair production at the LHC.We consider a fermiophobic scenario, with decays into a pair of gauge bosons, and a fermiophilic one, with decays into top and bottom quarks.After establishing the current bounds on simplified models, we focus on an SU(5)/SO(5)

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